By comparing patient PBMC before and after treatment, we saw no decrease in the functional response to any cytokine, in fact CD4 T cells showed significantly higher STAT5 activation with IL-2 stimulation following therapy, and the STAT5 response to IL-7 increased in individual patients but did not achieve significance as a group (Fig. 2 ).
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A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma.
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