Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain.

Expression of the NT5C2 allele in phase with the ch10_104957618_I risk allele was also reduced in all assayed adult brain regions (mean DLPFC: 15%, hippocampus: 12%, caudate: 13%), with highly significant differences in allele ratios observed between cDNA and genomic DNA that survived Bonferroni correction in all areas (DLPFC: P = 1.03 × 10 −4 , corrected P = 0.003; hippocampus: P = 2.64 × 10 −6 , corrected P = 8.46 × 10 −5 ; caudate P = 8.11 × 10 −5 , corrected P = 0.0025).

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