High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia.

After 4 weeks of HFD, we detected a slight trend towards a higher number of myeloid cells in the hypothalamus, while after 8 weeks of HFD, a time point when the mice exhibit a 50 % increase in body weight and elevated serum leptin level (Supplementary figure 1a–d), the number of Iba1+ cells was significantly higher than in chow-fed mice (Fig. 1 a, c).

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