Micro-computed tomography (Micro-CT) analysis of 10-week-old male mice revealed a highly significant decrease of bone density in Dicer Runx2Cre mice compared to Dicer flox mice ( Fig. 2H ).
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Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.
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