a decreasing trendp = .16
To investigate potential phenotypic maturation of cells in ECM scaffolds, mRNA transcripts of fetal markers CYP3A7 and AFP in iPSC hepatocytes grown in ECM scaffolds displayed a decreasing trend at day 14 (CYP3A7, 49% of sandwich control [ p = .16]; AFP, 47% of sandwich control [ p = .041]).