An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.

Second, in order to identify groups of sites that may not contain highly significant individual DMPs but are instead characterized by an extended region of contiguous differential DNA methylation associated with schizophrenia, we used a sliding window approach (see Methods ) [ 33 ], using permutations to establish an appropriate multiple testing threshold (set at P < 3 × 10 −7 for 5 % family-wise error).

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