Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.

16 However, these results require replication in larger studies; for example, variants in the RORA gene previously implicated in a GWAS of PTSD failed to attain significance in a larger replication effort. 17 No significant findings from the anxiety literature to date had previously been considered in candidate gene studies. 12 To our knowledge, this is the first GWAS to examine response to psychological therapy in any disorder, and the first to examine treatment response of any kind in anxiety disorders.

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Three independent clumps were suggestive of significance in the 6-month follow-up analysis ( Table 2 and Fig. 3 ), with no evidence of inflation (lambda = 1.02, Fig. 4 ).

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