In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways.

CoQ 0 inhibits expression of c-myc, cyclin D, and survivin in melanoma cells CoQ 0 significantly inhibited the β-catenin in B16F10 cells; it is logical to speculate that down-regulation of β-catenin's transcriptional targets, including c-myc, cyclin D, and survivin, may be significant evidence of CoQ 0 -induced growth inhibition in melanoma cells.

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