Leg edema with (S)-amlodipine vs conventional amlodipine given in triple therapy for hypertension: a randomized double blind controlled clinical trial.

After 120 days of therapy, pitting edema score increased significantly in racemic amlodipine group compared to (S)-amlodipine ( p = 0.038) and increment of score was highly significant ( p < 0.0001) with amlodipine compared with baseline value (Table 2 ).

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