highly significantP << 0.001
In the flexible part of the protein mutants of sector, conserved and core residues do not differ significantly from the remaining residues ( P > 0.05 for all comparisons, Mann-Whitney U -tests, Figure 5a ), while in the region containing the DDE domain there is a highly significant difference ( P << 0.001 for all comparisons, Mann-Whitney U -tests, Figure 5b ).