highly significantp < 0.05
P values of p < 0.0001 (****) and p < 0.001 (***) were considered most significant, p < 0.01 (**) highly significant, and p < 0.05 (*) significant.
P values of p < 0.0001 (****) and p < 0.001 (***) were considered most significant, p < 0.01 (**) highly significant, and p < 0.05 (*) significant.