Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex.

Because the relatively stable α-helical segments in the secondary structure of PTH (1-34) are important for receptor binding and activation of PTH (1-34), the retention of secondary structure in the PTH/LysDOCA complex may be significant for the bioactivity of PTH (1-34). 28 The formation of nanocomplexes was confirmed by dynamic light-scattering and TEM.

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