Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-α (HIF1-α) in an Ovine Model of Acute Myocardial Infarction.

26 In a recent study, a highly significant correlation was demonstrated between the proliferative cardiomyocytes and overexpression of HIF1‐α downstream genes in the peri‐infarct myocardium in primates. 27 VEGF, one of the HIF1 downstream genes, has been shown to induce adult cardiomyocyte mitosis in large mammalian models of ischemic heart disease. 28 , 29 , 30 It is therefore possible that overexpression of VEGF in our BMMSC‐HIF‐treated sheep promoted cardiomyocyte proliferation.

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