Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes.

PLoS One · 2016 · PMC5017692 · PMID 27611906

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In contrast, in the in vivo preovulatory-aged MII oocytes there was a highly significant decrease in the overall protein abundance of the cortical region and the spindle chromosome complex (Figs 3F and 4G ; Control: n = 41, PreOA: n = 120; p < 0.001).

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