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Esomeprazole- or rabeprazole-based triple therapy eradicated <i>Helicobacter pylori</i> comparably regardless of clarithromycin susceptibility and CYP2C19 genotypes.

J Clin Biochem Nutr · 2016 · PMC5018575 · PMID 27698544

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an increasing trendno p-value reported
( 21 ) documented an increasing trend in primary CAM resistance of H. pylori , rising from 8.7% (1997–2000) to 34.4% (2007–2008) in Japan.

also in 63,971 other papers

a decreasing trendno p-value reported
( 4 ) also reported a decreasing trend in H. pylori eradication rates, with H. pylori eradication rates significantly decreasing from 78.5% in 2001 to 66.5% in 2010.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.