( 21 ) documented an increasing trend in primary CAM resistance of H. pylori , rising from 8.7% (1997–2000) to 34.4% (2007–2008) in Japan.
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Esomeprazole- or rabeprazole-based triple therapy eradicated <i>Helicobacter pylori</i> comparably regardless of clarithromycin susceptibility and CYP2C19 genotypes.
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( 4 ) also reported a decreasing trend in H. pylori eradication rates, with H. pylori eradication rates significantly decreasing from 78.5% in 2001 to 66.5% in 2010.