Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction. An immunohistochemical, histopathological, and clinical comparative study.

As shown in Table 2 , there were statistically significant differences between final average staining scores of the 2 groups, in terms of cytoplasmic SHH ( p =0.01), nuclear TBX18 ( p =0.01) and cytoplasmic TSHZ3 ( p =0.01) staining, as well as a borderline significance in nuclear TSHZ3 ( p =0.05) staining.

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