Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents.

Intensive research demonstrates that natural product and/or natural product structures continued to play a highly significant role in the drug discovery and development process 2 . β-carboline and its saturated analogue are common structural motifs in natural products and pharmaceuticals 3 . β-carboline alkaloids were originally isolated from Peganum harmala, which have been used as a traditional herbal drug for hundreds of years in cancer in Northwest China 4 .

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