Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma.

Pooled from quadruplicate experiments, the highest level of necrosis plus apoptosis was seen with the PB combination in all cell lines from 56% to 80%, followed by EB from 41% to 73% and lastly with EY from 31% to 65% (one-way analysis of variance, P = .03) ( Figure 2 B ).When a two-way analysis of variance was undertaken, the influence of different CBs was highly significant ( P = .002), but ER status was not ( P = .3).

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All cell lines demonstrated a decreasing trend of confluence or increasing efficacy in cell proliferation suppression in that PB > EB > EY.

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Although there was no clear pattern of increase in apoptosis or necrosis by the three CBs in these cell lines, taken together, there was an increasing trend toward increasing cell death by necrosis plus apoptosis caused by these CBs in all cell lines (PB > EB > EY).

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