Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder.

Correlations between FA, AD and RD values, and SLC6A4 DNA methylation status A significant inverse correlation between the FA values of the body of the corpus callosum and SLC6A4 DNA methylation at CpG3 was observed for patients with MDD (Pearson's correlation: r =−0.493, P =0.003; Table 4 and Figure 3 ), in conjunction with a marginally significant inverse correlation at CpG4 (Pearson's correlation: r =−0.438, P =0.01; Table 4 ).

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