Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.

However, the pharmacogenetic interaction was only on the cusp of significance for three of the many end points tested: the anatomical ROI for caudate ( P =0.05), the functional ROI for amygdala ( P =0.057), and one of the self-reported questionnaire subscales (POMS-B confusion) in the alcohol infusion experiment ( P =0.02).

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There were no significant effects of treatment, genotype, or treatment × genotype interaction on hedonic evaluation of fatty and sugary food samples; the period effect was highly significant on many of these scales (see Supplementary Tables S10–S12 ).

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