Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.

Together, these data suggest that the MS/MS analysis yielded highly significant data for changes in protein levels. 3.3 Acute Global Alterations at the Protein Level Show a Unique and Distinct Pattern in Irradiated Brain The proteomic data were divided into four groups ( Figure S2A ) as follows: WT RT :WT CT (where average values of wild-type (WT) mice treated with radiation were divided by WT untreated controls); KO CT :WT CT (where average values of Sirt2 KO untreated controls were divided by WT untreated controls); and KO RT :KO CT (where average values of Sirt2 KO mice treated with radiation were divided by Sirt2 KO untreated controls).

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