Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.

Importantly, an increasing trend was observed during the precancerous progression of ESCC, from mild (median, 299.40 ng/mL) to moderate (median, 323.03 ng/mL) and severe dysplasia; this finding was not age- or gender-dependent in the healthy donors (Spearman's rank correlation test for age, P = 0.314; Mann-Whitney test for gender, P = 0.617).

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