The effect of domiciliary noninvasive ventilation on clinical outcomes in stable and recently hospitalized patients with COPD: a systematic review and meta-analysis.

For stable patients, there was no evidence of a survival benefit from NIV (relative risk [RR] 0.88 [0.55, 1.43], I 2 =60.4%, n=7 RCTs), but there was a possible trend toward fewer hospitalizations (weighted mean difference −0.46 [−1.02, 0.09], I 2 =59.2%, n=5 RCTs) and improved health-related quality of life.

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In this context, it is worth noting that the study by Köhnlein et al 23 had the highest hypercapnia threshold as an eligibility criterion (PaCO 2 $7 kPa), and also showed a statistically significant survival benefit (and a nonsignificant trend toward fewer hospital admissions).

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