highly significantp < 0.001
No significant difference ( p = 0.872) was observed between patients (65.18 ± 16.69) and parents (66.01 ± 19.98) (Additional file 3 : Table S3); but the difference between patients and age-matched controls (54.35 ± 21.37) was highly significant ( p < 0.001), with increased methylation in the patients (Fig. 2 ).