Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.

Whereas mixed TCRαβ + and TCRγδ + IELs showed minor CD25 upregulation upon co-culture with EV, L1, or L6 cells, IELs exposed to L1+6 cells showed highly significant CD25 upregulation, wholly attributable to ∼20% of Vγ7 + cells (both Vγ7GL2 + and Vγ7GL2 − cells) ( Figure 6 A).

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