highly significantp = 2.21 × 10 −12
Indeed, on average, the percentage contribution of such cells to the ICMs of each assayed and p38-Mapk14/11 inhibited group only represented 14.2%, 10.8% and 14.1% (when assaying for Gata6, Sox17 and Gata4, respectively) compared with an average of 36.9% in control embryo groups (when considered together across the three assayed conditions); PrE cell number reductions were associated with highly significant p -values (i.e. < 0.005, two-tailed Student's t -test; p = 2.21 × 10 −12 , 8.40 × 10 −7 and 2.54 × 10 −12 , when respectively assaying Gata6, Sox17 and Gata4).