Current perspectives on cardiovascular outcome trials in diabetes.

The PROactive trial [ 25 ] on the CV safety of the addition to usual care of pioglitazone versus placebo found a slight trend toward a combined primary CV end-point—CVD and interventions in all vascular beds reduction—(10 % reduction, p = 0.095) and a significant 16 % reduction in the secondary end-point (MI, stroke, all-cause mortality).

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