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Seroprevalence of Hepatitis E Virus in Iran: A Systematic Review and Meta-analysis.

Middle East J Dig Dis · 2016 · PMC5045671 · PMID 27698968

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a decreasing trendno p-value reported
The infection seems to have a decreasing trend overtime, which might be related to improved sanitation and better access to safe water but the pattern is not uniform across the entire country with existence of certain confounders such as mobility along borders especially to countries with high endemicity of HEV.

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