MicroRNA profiling of patient plasma for clinical trials using bioinformatics and biostatistical approaches.

Of the miRNAs found in the biostatistical approach, 3/10 most highly significant miRNAs (miR-1183, 1200, and 1245-5p) were not found in the rank-based approach as the miRNAs also had high values in normal donor controls.

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Second, miRNAs with borderline significance can be added to the lists based on the rank-based method, but this should be done only in a hypothesis-generating experiment to be tested on well-defined patient populations.

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