Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

Furthermore, we observed decreased Rab18 expression (that failed to attain significance, P = 0.06), which has been associated with impaired fat storage ( Pulido et al., 2011 ), and aberrant processing of lipids in adipose tissue ( Pulido et al., 2013 ) ( Fig. 5 F).

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This is highly significant within the context of obesity as the capacity to expand the number of adipocyte cells to accommodate increased lipid storage requirements is a key determinant of the degree of metabolic dysfunction that accompanies increased adiposity.

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