Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial.

In considering results for each outcome, it is important to allow for any changes over time which might have occurred regardless of active treatment; hence changes in the placebo group are also shown. Potassium In the placebo arm, the change in the mean potassium level in year one compared to year zero was close to zero but there was a marginally significant increase in year 2 compared to year 1 of 0.02 mmol/L.

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