Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy.

As described above, maximal respiratory capacity of cells, was significantly lower in the cells cultured for 8 days in HG when compared to the controls, and this reduction became highly significant (P<0.0001) after 12 days of culture in HG, with 3 fold reduction of maximal OCR (P<0.0001, Fig. 3 A) and 4 fold reduction in the reserve capacity when compared to cells cultured in NG (P<0.001).

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