Toll-like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan.

When the ratio of IFNγ:IL-10 production was calculated, an increased ratio was recorded in TLR6 −/− mice when compared to TLR2 −/− mice at week 10 p.i., which was almost significant ( U = 2, P = 0.064), suggesting that TLR6 −/− mice have an enhanced ability to promote a Th1 immune response which is linked to enhanced resistance to infection (Fig. 4c ).

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