Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes.

However, we suggest, based on results of borderline significance ( p values: 0.025–0.079) that the level of 17β-estradiol for women with the minor genotype for rs3020364 , rs24744148 and rs2982712 were lower throughout the cycle in women with low (<28.5 %) percent mammographic density and higher in women with high (>28.5 %) percent mammographic density, when compared to women with the major genotype.

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When comparing the minor homozygous genotypes to the heterozygous, the odds of above median mammographic were higher for the heterozygous, but only significant for rs2982712 (OR: 3.48, p -value 0.014) (Table 3 ). When examining the 17β-estradiol concentrations throughout the menstrual cycle for women with high and low percent mammographic density separately (median split of percent mammographic density) using linear mixed models we found a striking, albeit only borderline significant pattern for 3 of our 8 SNPs; the level of 17β-estradiol for women with the minor aa genotype for rs3020364 , rs24744148 and rs2982712 were lower throughout the cycle for women with low (<28.5 %) percent mammographic density and higher throughout the cycle for women with high (>28.5 %) percent mammo

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