28 , 44 , 45 , 46 These analyses confirmed a highly significant 80% reduction in GFAP-positive processes for both WFA and SB, and 60% and 80% reductions in GCL apoptosis, respectively ( Figure 1i and j ).
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Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.
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Surprisingly, out of a panel of 27 cytokines and growth factors assessed, only TNF- α levels were significantly altered by WFA, although, negative trends were also identified for IL-1 α and β , and EGF, and a positive trend for IL-10 ( Table 1 ).