Time trend analysis of primary liver cancer incidence in Sihui county of Guangdong Province, China (1987-2011).

Moreover, the average ASR in this region exhibited an increasing trend over this period, in contrast to three other endemic regions of China, Shanghai [ 14 ], Qidong [ 15 ], and Fusui [ 16 ], where incidence rates are stable or declining.

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Several studies have reported a decreasing trend in some epidemic regions of China, such as Shanghai, Qidong and Fusui [ 14 – 16 ], but changes in PLC incidence have not been examined in southern China.

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