Barely Significant
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Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial.

Clin Cosmet Investig Dermatol · 2016 · PMC5063591 · PMID 27785083

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highly significantno p-value reported
Table 3 shows a significant increase in L * and ITA° after 12 weeks of L/Zi supplementation compared to baseline and also shows a highly significant decrease in skin sallowness after L/Zi supplementation over baseline.

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