Likewise, we did not detect a statistically significant change in conductance, though an increasing trend is observed, or voltage sensitivity on magnetic stimulation at each stage of the stimulation protocol for both constructs targeting the voltage sensor domain: K v 1.2-BBS-S1-S2 (change in conductance=17.0±5.6% (before), 16.8±7.5% (during), 17.3±8.1% (after); for all pairs P >0.01, n =7 cells, paired t -test) and K v 1.2-BBS-S3-S4 (change in conductance=18.5±3.2% (before), 12.8±3.8% (during), 11.5±4.7% (after); for all pairs P >0.01, n =5 cells, paired t -test; Fig. 4b-d ; Supplementary Table 1 ).
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Localized force application reveals mechanically sensitive domains of Piezo1.
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