Methylome analysis for spina bifida shows <i>SOX18</i> hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development.

Clin Epigenetics · 2016 · PMC5064967 · PMID 27757173

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highly significantno p-value reported

Among these 370 highly significant CpGs, 58 % are hypomethylated in patients with NTDs.

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