The High Prevalence of Functional Complement Defects Induced by Chemotherapy.

Now that we have established highly significant complement defects in some of the oncology treatment regimens, additional studies should be designed to determine the positive or negative effects of the complement system (antitumor and/or increased risk of infection), which may be more relevant in children being more dependent on the innate immune system than in adults, which may have preexisting specific antibodies being largely absent in young oncology patients.

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