Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.

Multiple studies have investigated the relationship between the Ser9Gly polymorphism and antipsychotic response; however, they have produced conflicting results, with a meta-analysis observing a nonsignificant trend between the Ser9 allele and decreased antipsychotic response (odds ratio=0.82; 95% confidence interval, 0.65-1.04). 80 Additionally, multiple studies have reported a significant association between Ser9Gly and TD 52 ; however, three separate meta-analyses provide inconsistent findings with only a modest to nonexistent effect for the Gly9 allele with increased TD risk. 58 , 81 , 82 Dopamine system: COMT Catechol- 0 -methyltransferase (COMT) is a key enzyme for dopamine clearance and metabolic termination of dopamine activity and has been investigated in antipsychotic association studies.

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