highly significantp-value = 5.6E-12
In support of their tissue of origin, ingenuity disease and function pathway analysis of the differentially expressed genes between Ly6C hi TAMs or F4/80 hi TAMs versus colonic lpMFs revealed highly significant enrichment for pathways associated with gastrointestinal tract cancer and tumors (Ly6C hi TAMs: p-value = 5.6E-12, activation z score = 2.68; F4/80 hi TAMs: p-value = 1.1E-09, activation z score = 2.5) and with intestinal inflammation (Ly6C hi TAMs: p-value = 9.2E-11, activation z score = 2.38; F4/80 hi TAMs: p-value = 8.3E-07, activation z score = 2.68; Table S3).