A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia.

The rs3130000-A allele (corresponding to rs3129996-A) is associated with a highly significant reduction in the expression of both ABCF1 gene ( P -values P =8.06 × 10 −11 and P< 10 −8 , in the respective databases) and HCG27 gene ( P -values P =2.17 × 10 −17 and P <10 −5 , respectively).

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