Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases.

Since minSNP gene scores are misleadingly small ( Figure 2A , Figure S2 , and Figure S16 ), single highly significant genes pull in many unrelated genes with low gene scores to create artifactual “star-shaped” subnetworks that are likely false positives (see Figure S10 for HotNet2 results using minSNP gene scores for ulcerative colitis).

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