In a large sample of Japanese schizophrenia individuals, the association between the mental disorder and two single nucleotide polymorphisms of PLAT, the human tPA gene, rs2020922 and rs8178817, was highly significant. 32 Protein S: mechanism of action in the blood and the brain Protein S is a natural anticoagulant that circulates in an active free form, or bound to C4b-binding protein, one of the complement inactivator proteins ( Figure 3 ). 33 Free-protein S forms a complex with activated protein C that inacti
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