highly significantP < 0.005
The RA patients with an insufficient response to MTX who received the tacrolimus-MTX combination showed highly significant improvement in the DAS28 after 4 weeks (n = 10, baseline: 4.51 ± 0.31 to 4.03 ± 0.28, P < 0.005), 12 weeks (n = 9, baseline: 4.59 ± 0.34 to 3.38 ± 0.29, P < 0.01) and 24 weeks (n = 8, baseline: 4.45 ± 0.35 to 3.12 ± 0.34, P < 0.01) ( Figure 1 ).