Getting into the brain: liposome-based strategies for effective drug delivery across the blood-brain barrier.

Transferrin liposomes have been reported to be able to deliver borocaptate (BSH) and small interfering RNA (siRNA) into the CNS, which is highly significant, because these compounds do not readily cross the BBB. 224 , 246 , 263 In the same way, the covalent binding of lactoferrin to the liposome surface proved to be an effective strategy for the treatment of brain tumors. 244 In glioma therapy, similarly to the BBB, the BBTB also represents a challenge for glioma-targeted delivery. 300 Fortunately, many kinds of receptors are highly expressed in the BBTB (tumor vessels and/or glioma cells), and these receptors have been explored for the design of actively targeting liposomes for brain delivery of anticancer drugs across the BBTB.

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