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High-frequency oscillatory ventilation is an effective treatment for severe pediatric acute respiratory distress syndrome with refractory hypoxemia.

Ther Clin Risk Manag · 2016 · PMC5077263 · PMID 27799777

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a decreasing trendno p-value reported
We also observed a decreasing trend in PaCO 2 during the first 72 hours.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.