Effects of a novel β-lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis.

The naphtoquinone significantly ( p < 0.05) diminished the protozoan proliferation at 20 μM and the inhibition was highly significant ( p < 0.001) at 30–50 μM, producing 19 μM IC 50 . 3.2 Cytotoxicity In order to test its possible selectivity, the compound was assayed on mammalian cells.

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