an increasing trendP = 0.203
In keeping with gene expression and mtDNA results, improved mitochondrial function was evidenced by decreased levels of nuclear-encoded COX4 at week 24 [−56.3% (−65%, −29.6%), P = 0.016, Figure 3 c] and by an increasing trend in mitochondrially encoded COX2 at week 24 [+64.1% (+21.2%, +110.9%), P = 0.203, Figure 3 d], resulting in a significant increase in the COX2/COX4 ratio at week 24 [+288% (+42.2, +621.7), P = 0.038], in contrast to the changes observed previously in tNRTI-mediated SAT toxicity. 18 , 33 Also observed were significantly reduced levels of the inflammatory marker B2M at week 2 [−48.7% (−60.2%, −22.6%), P = 0.02] but not at week 24 (Figure 3 e).